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Bis imino pyridine ligand pharmaceuticals

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The hydrogenation reactions can be carried out by charging a thick walled glass vessel with an olefin and a transition metal-containing compound represented by formula I. These rings can also, optionally, be substituted with a substituting group defined above. Search Advanced. The same hydrogenation as Example 1 was carried out in these examples, with the exception of replacing olefin A with olefins B to I shown below in Scheme 4. Stanislav Groysman. Preferably, each of R 2 and R 5 represents a methyl group, an ethyl group, an n-propyl group or an isopropyl group. However, there is no disclosure in these references of hydrogenating prochiral olefins in the presence of these transition metal compounds, nor is there any disclosure that the compounds disclosed therein would be efficient for this reaction. Example 10 Hydrogenation of Substrate I in the Presence of Compound 2 The same reaction of Example 9 was carried out, except that the olefin I was hydrogenated in the presence of compound 2. Representative, but not limited to, cobalt-containing compounds represented by formula I are shown below in Scheme It is possible for cyclometallated compounds to be formed when one of R 6 and R 7 are bound to the metal center M, where, in these compounds, R 1 represents a chemical bond between metal center M and R 6 or R 7.

  • bis(imino)pyridine iron C5H5FeN3 ChemSpider
  • Adnan AbuSurrah Google Scholar Citations

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    Stabilizing Terminal Ni(III)–Hydroxide Complex Using NNN-Pincer Ligands:. Synthesis of a Highly Porous Bis(imino)pyridine-Linked Polymer and Its.

    Synopsis. Addition of lithium amides such as LiNMe2 or KN(SiMe3)2 to the bis( imino)pyridine ferrous dichloride resulted in deprotonation of the methyl groups of. The aryl substituted bis(imino)NHC complexes produce tridentate ligands, while the pyridine exchanged NHC forms.
    The present inventors have found that these transition metal-containing compounds are highly active in the hydrogenation of olefins, particularly prochiral olefins, that prove challenging for current catalysts.

    One object of the present invention is to provide transition metal-containing compounds having tridentate ligands, where the transition metal is iron, nickel, or cobalt and the tridentate ligands have at least one chiral moiety.

    images bis imino pyridine ligand pharmaceuticals

    Other Databases. The transition metal-containing compound according to claim 1, wherein M represents a cobalt atom.

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    The substituent groups do not substantially interfere with the hydrogenation processes described herein. The star indicates the chiral carbon atom:.

    images bis imino pyridine ligand pharmaceuticals
    Bis imino pyridine ligand pharmaceuticals
    The reaction is shown below in Scheme 3.

    In other preferred embodiments, the blocking group is a group represented by formula IV.

    bis(imino)pyridine iron C5H5FeN3 ChemSpider

    A method, comprising hydrogenating an olefin in the presence of a catalyst according to claim The same reaction as Example 13 was carried out, except that compound 3 was replaced with compound 7. This percentage and the enantiomeric excess values were determined with a gas chromatography GC flame ionization detector. The transition metal-containing compound according to claim 1, wherein M represents an iron atom.

    The large majority of the previously reported bis(imino)pyridine ligands encompass ketimine sidearms.

    Specifically for nickel, several groups have recently. Structure, properties, spectra, suppliers and links for: bis(imino)pyridine iron.

    Neutral Bis(imino)-1,4-dihydropyridinate and Cationic Bis(imino)pyridine σ- Alkylzinc(II). σ-organometallic chemistry with 2,6-bis (imino)pyridine ligands: New.
    This percentage and the enantiomeric excess values were determined with a gas chromatography GC flame ionization detector. Organometallics23,and Zhu et al. The contents of the first and second glass vessels were mixed and transferred to a thick-walled glass vessel, which was submerged in liquid nitrogen and attached to a vacuum line.

    Reed, S. Additional rings can be present in the hetero aryl groups, which may be fused or connected together by single bonds to the other aryl rings.

    Adnan AbuSurrah Google Scholar Citations

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    In the transition metal-containing compounds represented by formula IY 2 represents a chemical bond between X 2 and Z 2 or a carbon-containing group that links X 2 and Z 2.

    If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center.

    The transition metal-containing compound according to claim 1, wherein M represents a cobalt atom. The invention also relates to methods of hydrogenating and transforming olefins and alkynes with iron-containing compounds having tridentate achiral ligands.

    images bis imino pyridine ligand pharmaceuticals

    Many of these compounds are known and the syntheses for these compounds can be found in, e. The transition metal-containing compound according to claim 1, wherein each R1, individually, represents a chemical bond to a carbon atom of Z1 or Z2, a hydrogen atom, or a C alkyl group.